Fmoc-Amino Acids

Solid phase peptide synthesis (SPPS) has been the most efficient method for the preparation of peptides since its introduction in 1963 by Bruce Merrifield. The t-Boc amino acid derivatives had been used dominantly for the SPPS until the Fmoc chemistry was introduced to overcome the t-Boc chemistry problems, repetitive TFA treatment which might catalyze the side reactions and cleave the peptide chain prematurely. In Fmoc synthesis, the growing peptide is subjected to mild base treatment using piperidine to remove the Fmoc group, and TFA is required only for the final deprotection and cleavage from the resin. The comparison experiments [1] between Fmoc and t-Boc approache indicate that Fmoc chemistry is more reliable and tends to give the desired peptides in better purities.

[1] G. B. Fields, et al. Int. J. Peptide Protein Res., 1990, 35, 161.

01011

Na-(9-Fluorenylmethoxycarbonyl)-

L-alanine

C18H17NO4, MW 311.3

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 18.5 1.00

5 g

25 g

100 g

$8

$35

$100

01012

Na-(9-Fluorenylmethoxycarbonyl)-D-alanine

C18H17NO4, MW 311.3

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$50

$215

$690

03012

Na-(9-Fluorenylmethoxycarbonyl)-

Na-methyl-D-alanine

C19H19NO4, MW 325.3

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$90

$360

$1,440

03013

Na-(9-Fluorenylmethoxycarbonyl)-

3-(1-naphthyl)-L-alanine

C28H23NO4, MW 437.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$110

$450

$1,800

03014

Na-(9-Fluorenylmethoxycarbonyl)-

3-(1-naphthyl)-D-alanine

C28H23NO4, MW 437.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$95

$380

$1,520

03015

Na-(9-Fluorenylmethoxycarbonyl)-

3-(2-naphthyl)-L-alanine

C28H23NO4, MW 437.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$95

$380

$1,520

03016

Na-(9-Fluorenylmethoxycarbonyl)-

3-(2-naphthyl)-D-alanine

C28H23NO4, MW 437.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$95

$380

$1,520

01021

Na-(9-Fluorenylmethoxycarbonyl)-Ng -

(2,2,4,6,7-pentamethyl-dihydrobenzofuran-

5-sulfonyl)-L-arginine

C34H40N4O7S, MW 648.8

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 5.5 0.50

5 g

25 g

100 g

$80

$300

$950

01022

Na-(9-Fluorenylmethoxycarbonyl)-Ng -

(2,2,4,6,7-pentamethyl-dihydrobenzofuran-

5-sulfonyl)-D-arginine

C34H40N4O7S, MW 648.8

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$60

$250

$980

01023

Na-(9-Fluorenylmethoxycarbonyl)-Ng -

4-methoxy-2,3,6-trimethyl-benzenesulfonyl-

L-arginine

C31H36N4O7S, MW 608.7

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$50

$220

$650

01024

Na-(9-Fluorenylmethoxycarbonyl)-Ng -

4-methoxy-2,3,6-trimethyl-benzenesulfonyl-

D-arginine

C31H36N4O7S, MW 608.7

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$35

$140

$560

01031

Na-(9-Fluorenylmethoxycarbonyl)-Nb -

trityl-L-asparagine

C38H32N2O5, MW 596.7

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 14.5 1.00

5 g

25 g

100 g

$60

$200

$640

01041

Na-(9-Fluorenylmethoxycarbonyl)-b -

(t-butyl ester)-L-aspartic acid

C23H25NO6, MW 411.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 24.5 1.00

5 g

25 g

100 g

$45

$180

$540

03141

Na-(9-Fluorenylmethoxycarbonyl)-b-

cyclohexyl-L-alanine

C24H27NO4, MW 393.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$40

$160

$650

03142

Na-(9-Fluorenylmethoxycarbonyl)-b-

cyclohexyl-D-alanine

C24H27NO4, MW 393.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$60

$250

$980

01051

Na-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

C37H31NO4S, MW 585.7

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: +21.0 1.00

5 g

25 g

100 g

$45

$160

$500

01053

Na-(9-Fluorenylmethoxycarbonyl)-S-

acetamidomethyl-L-cysteine

C21H22N2O5S, MW 414.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 32.0 1.00

5 g

25 g

100 g

$45

$180

$540

01061

Na-(9-Fluorenylmethoxycarbonyl)-Ng -

trityl-L-glutamine

C39H34N2O5, MW 610.7

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 1.6 0.50

5 g

25 g

100 g

$60

$200

$640

01071

Na-(9-Fluorenylmethoxycarbonyl)-g -

(t-butyl ester)-L-glutamic acid

C24H27NO6, MW 425.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 17.0 1.00

5 g

25 g

100 g

$50

$200

$590

01081

Na-(9-Fluorenylmethoxycarbonyl)-glycine

C17H15NO4, MW 297.3

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$10

$35

$110

03081

Na-(9-Fluorenylmethoxycarbonyl)-Na-methyl-glycine

C18H17NO4, MW 311.3

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$50

$230

$920

01091

Na-(9-Fluorenylmethoxycarbonyl)-Nim-

trityl-L-histidine

C40H33N3O4, MW 619.7

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: + 88.0 5.00

5 g

25 g

100 g

$35

$140

$430

01101

Na-(9-Fluorenylmethoxycarbonyl)-L-isoleucine

C21H23NO4, MW 353.4

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 12.0 1.00

5 g

25 g

100 g

$10

$35

$110

01111

Na-(9-Fluorenylmethoxycarbonyl)-L-leucine

C21H23NO4, MW 353.4

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 25.0 1.00

5 g

25 g

100 g

$10

$35

$110

01112

Na-(9-Fluorenylmethoxycarbonyl)-D-leucine

C21H24NO4, MW 353.4

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$60

$250

$980

03111

Na-(9-Fluorenylmethoxycarbonyl)-Na -

methyl-L-leucine

C22H25NO4, MW 367.4

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$50

$230

$920

01121

Na-(9-Fluorenylmethoxycarbonyl)-Ne -

(t-butyloxycarbonyl)-L-lysine

C26H32N2O6, MW 468.6

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 12.0 1.00

5 g

25 g

100 g

$40

$140

$440

01123

Na,Ne-Di(9-fluorenylmethoxycarbonyl)-L-lysine

C36H34N2O6, MW 590.7

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$45

$180

$540

01131

Na-(9-Fluorenylmethoxycarbonyl)-L-methionine

C20H21NO4S, MW 371.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 29.0 1.00

5 g

25 g

100 g

$10

$40

$110

01132

Na-(9-Fluorenylmethoxycarbonyl)-D-methionine

C20H21NO4S, MW 371.5

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$75

$305

$980

01141

Na-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine

C24H21NO4, MW 387.4

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 40.0 1.00

5 g

25 g

100 g

$10

$35

$110

01142

Na-(9-Fluorenylmethoxycarbonyl)-D-phenylalanine

C24H21NO4, MW 387.4

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$50

$200

$720

03143

Na-(9-Fluorenylmethoxycarbonyl)-Na-

methyl-L-phenylalanine

C25H23NO4, MW 401.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$60

$235

$940

01151

Na-(9-Fluorenylmethoxycarbonyl)-L-proline

C20H19NO4, MW 337.4

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 32.0 1.00

5 g

25 g

100 g

$10

$35

$110

01152

Na-(9-Fluorenylmethoxycarbonyl)-D-proline

C20H19NO4, MW 337.4

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$18

$70

$290

01161

Na-(9-Fluorenylmethoxycarbonyl)-L-serine

C18H17NO5, MW 327.3

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$65

$270

$860

01162

Na-(9-Fluorenylmethoxycarbonyl)-D-serine

C18H17NO5, MW 327.3

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$35

$140

$560

01163

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-L-serine

C22H25NO5, MW 383.4

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: + 26.0 1.00

5 g

25 g

100 g

$50

$185

$590

01164

Na-(9-Fluorenylmethoxycarbonyl)-O-

(t-butyl ether)-D-serine

C22H25NO5, MW 383.4

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$40

$160

$650

01165

Na-(9-Fluorenylmethoxycarbonyl)-

O-benzylphospho-L-serine

C25H24NO8P, MW 497.4

TLC purity 97%, HPLC purity 95%

1 g

5 g

$125

$500

01171

Na-(9-Fluorenylmethoxycarbonyl)-L-threonine

C19H19NO5, MW 341.4

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$45

$180

$650

01172

Na-(9-Fluorenylmethoxycarbonyl)-D-threonine

C19H19NO5, MW 341.4

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$70

$275

$1,100

01173

Na-(9-Fluorenylmethoxycarbonyl)-O-

(t-butyl ether)-L-threonine

C23H27NO5, MW 397.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 5.5 0.50

5 g

25 g

100 g

$50

$185

$600

01174

Na-(9-Fluorenylmethoxycarbonyl)-O-

(t-butyl ether)-D-threonine

C23H27NO5, MW 397.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$45

$180

$720

03211

Na-(9-Fluorenylmethoxycarbonyl)-L-

1,2,3,4-tetrahydro-isoquinoline-

3-carboxylic acid

C25H21NO4, MW 399.4

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

$85

$340

03212

Na-(9-Fluorenylmethoxycarbonyl)-D-

1,2,3,4-tetrahydro-isoquinoline-

3-carboxylic acid

C25H21NO4, MW 399.4

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

$125

$500

01181

Na-(9-Fluorenylmethoxycarbonyl)-L-tryptophan

C26H22N2O4, MW 426.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 30.0 1.50

5 g

25 g

100 g

$15

$60

$180

01182

Na-(9-Fluorenylmethoxycarbonyl)-D-tryptophan

C26H22N2O4, MW 311.3

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$50

$215

$690

01183

Na-(9-Fluorenylmethoxycarbonyl)-Nin-

(t-butyloxycarbonyl)-L-tryptophan

C31H30N2O6, MW 526.6

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 21.0 2.00

5 g

25 g

100 g

$80

$320

$1,100

01184

Na-(9-Fluorenylmethoxycarbonyl)-Nin-

(t-butyloxycarbonyl)-D-tryptophan

C31H30N2O6, MW 526.6

TLC purity 98%, HPLC purity 98%

1 g

5 g

25 g

$50

$215

$860

01191

Na-(9-Fluorenylmethoxycarbonyl)-L-tyrisine

C24H21NO5, MW 403.4

TLC purity 98%, HPLC purity 98%

5 g

25 g

$110

$440

01192

Na-(9-Fluorenylmethoxycarbonyl)-D-tyrisine

C24H21NO5, MW 403.4

TLC purity 98%, HPLC purity 98%

1 g

5 g

$60

$230

01193

Na-(9-Fluorenylmethoxycarbonyl)-O-

(t-butyl ether)-L-tyrosine

C28H29NO5, MW 459.5

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 28.7 1.00

5 g

25 g

100 g

$40

$160

$480

01194

Na-(9-Fluorenylmethoxycarbonyl)-O-

(t-butyl ether)-D-tyrosine

C28H29NO5, MW 459.5

TLC purity 98.5%, HPLC purity 98.5%

1 g

5 g

25 g

$45

$180

$720

01195

Na-(9-Fluorenylmethoxycarbonyl)-O-

phospho-L-tyrisine

C24H22NO8P, MW 483.4

TLC purity 95%, HPLC purity 95%

1 g

5 g

$110

$440

01197

Na-(9-Fluorenylmethoxycarbonyl)-O-

benzylphospho-L-tyrisine

C31H28NO8P, MW 573.5

TLC purity 97%, HPLC purity 90%

1 g

5 g

$160

$640

01201

Na-(9-Fluorenylmethoxycarbonyl)-L-valine

C20H21NO4, MW 339.4

TLC purity 98.5%, HPLC purity 98.5%

Specific Rotation: - 17.7 1.00

5 g

25 g

100 g

$12

$35

$110

01202

Na-(9-Fluorenylmethoxycarbonyl)-D-valine

C20H21NO4, MW 339.4

TLC purity 98.5%, HPLC purity 98.5%

5 g

25 g

100 g

$60

$250

$800

03201

Na-(9-Fluorenylmethoxycarbonyl)-Na-methyl-L-valine

C21H23NO4, MW 353.4

TLC purity 98%, HPLC purity 98%

1 g

5 g

$85

$340